posted on 2020-12-22, 17:10authored byWeizhun Yang, Jicheng Zhang, Chia-Wei Yang, Sherif Ramadan, Richard Staples, Xuefei Huang
The
formation of an unprecedented 12-membered macrocyclic ketal
through the long-range participation of a levulinoyl group across
a glycosidic linkage was observed in glycosylation reactions. This
finding indicated that stereodirecting participation is not limited
to groups within the glycan ring being activated, thus broadening
the scope of remote group participation in glycosylation.