jm0507173_si_001.pdf (461.62 kB)
Download file

Lipid-Soluble 3-Pyridinol Antioxidants Spare α-Tocopherol and Do Not Efficiently Mediate Peroxidation of Cholesterol Esters in Human Low-Density Lipoprotein

Download (461.62 kB)
journal contribution
posted on 03.11.2005, 00:00 authored by Hye-Young Kim, Derek A. Pratt, Jennifer R. Seal, Maikel Wijtmans, Ned A. Porter
Because α-tocopherol (α-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare α-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.