Limonoids and Triterpenoids as 11β-HSD1 Inhibitors from Walsura robusta
journal contributionposted on 02.03.2016, 19:35 authored by Guo-Cai Wang, Jin-Hai Yu, Yu Shen, Ying Leng, Hua Zhang, Jian-Min Yue
Nine new cedrelone-type limonoid derivatives, walsunoids A–I (1–9), and 11 known compounds were isolated from the leaves of Walsura robusta. Walsunoid A (1) is a new degradation product of cedrelone-type limonoids, and walsunoid I (9) is a rare cedrelone-type limonoid amide. Their structures and absolute configurations were determined by spectroscopic data, single-crystal X-ray diffraction, and ECD data analyses. Five compounds showed moderate inhibitory activities against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 values ranging from 0.69 to 9.9 μM.