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Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Cinnamomum bejolghota Confirm Its Functional Food Property
journal contribution
posted on 2020-08-07, 14:04 authored by Li Rao, Yun-Xia You, Yu Su, Yue Fan, Yu Liu, Qian He, Yi Chen, Jie Meng, Lin Hu, Yizhou Li, You-Kai Xu, Bin Lin, Chuan-Rui ZhangIn
the aim to evaluate the functional food property of Cinnamomum bejolghota, seven new lignans and neolignans,
bejolghotins A–G (1–4 and 9–11), along with 14 known ones (5–8 and 12–21), were isolated and their structures including absolute configurations
were elucidated by extensive spectroscopic data and electronic circular
dichroism (ECD) analyses. All of the isolates were tested for antioxidant
and human cancer cell proliferation inhibitory activities. Twenty
compounds showed comparable antioxidant activity to the positive controls,
and three significantly inhibited the growth of three cancer cell
lines HCT-116, A549, and MDA-MB-231 with IC50 values of
0.78–2.93 μM, which confirmed its health benefits.
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food propertyHuman Cancer Cell Proliferation Inh...configurationspectroscopic dataonehealth benefitsLignandichroismIC 50 valuesFunctional Food PropertyHCTlignanNeolignanECDcompoundcancer cell proliferationanalysesbejolghotinantioxidant activityAntioxidantneolignanaimCinnamomum bejolghotaMDA-MB -231Cinnamomum bejolghota Confirm
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