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Light-Induced Isomerization of Apoptolidin A leads to Inversion of C2−C3 Double Bond Geometry

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posted on 2010-07-02, 00:00 authored by Brian O. Bachmann, Ruth McNees, Bruce J. Melancon, Victor P. Ghidu, Rachel Clark, Brenda C. Crews, Sean M. DeGuire, Lawrence J. Marnett, Gary A. Sulikowski
The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2−C3 carbon−carbon double bond of apoptolidin A.

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