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Light-Activated Chemically Reactive Fibrous Patch Revolutionizes Wound Repair Through the Prevention of Postoperative Adhesion
journal contributionposted on 2023-02-08, 14:30 authored by Xiaotong Wu, Jianmei Chen, Anwei Zhou, Yinfeng Zhao, Zihan Tian, Yiping Zhang, Kerong Chen, Xinghai Ning, Yurui Xu
A light-activated chemically reactive fibrous patch (ChemPatch) with tissue adhesion and wound healing activity was developed for preventing postoperative peritoneal adhesion. ChemPatch was constructed by an integrative electrospinning fabrication strategy, generating multifunctional PCL-NHS fibers encapsulating antioxidant curcumin and MnO2 nanoparticles. ChemPatch exhibited excellent photothermal conversion, which not only reformed the physical state to match the tissue but also improved conjugation between ChemPatch and tissues, allowing for strong attachment. Importantly, ChemPatch possessed good antioxidant and radical scavenging activity, which protected cells in an oxidative microenvironment and improved tissue regeneration. Particularly, ChemPatch acted as a multifunctional barrier and could not only promote reepithelialization and revascularization in wound defect model but simultaneously ameliorate inflammation and prevent postoperative peritoneal adhesion in a mouse cecal defect model. Thus, ChemPatch represents a dual-active bioadhesive barrier for reducing the incidence and severity of peritoneal adhesions.
wound healing activitywound defect modelsimultaneously ameliorate inflammationradical scavenging activityalso improved conjugationgenerating multifunctional pclactive bioadhesive barrierimproved tissue regeneration2 submultifunctional barriertissue adhesionstrong attachmentprotected cellspromote reepithelializationpostoperative adhesionphysical stateperitoneal adhesionsoxidative microenvironment