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Ligand-Enabled Meta-C–H Alkylation and Arylation Using a Modified Norbornene

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journal contribution
posted on 16.09.2015, 00:00 by Peng-Xiang Shen, Xiao-Chen Wang, Peng Wang, Ru-Yi Zhu, Jin-Quan Yu
2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd­(II)-catalyzed meta-C­(sp2)–H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.