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Ligand-Controlled Enantioselective [2 + 2] Cycloaddition of Oxabicyclic Alkenes with Terminal Alkynes Using Chiral Iridium Catalysts

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journal contribution
posted on 2010-01-15, 00:00 authored by Bao-Min Fan, Xiao-Jiao Li, Fang-Zhi Peng, Hong-Bin Zhang, Albert S. C. Chan, Zhi-Hui Shao
The first catalytic asymmetric [2 + 2] cycloaddition of oxabicyclic alkenes and terminal alkynes has been developed. This iridium-catalyzed enantioselective [2 + 2] cycloaddition allows the formation of four stereocenters in a single step with excellent enantioselectivity (94→99% ee).

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