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Ligand-Accelerated Palladium(II)-Catalyzed Enantioselective Amination of C(sp2)–H Bonds

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journal contribution
posted on 2020-07-31, 22:29 authored by Xiu-Fen Cheng, Fan Fei, Yan Li, Yi-Ming Hou, Xin Zhou, Xi-Sheng Wang
The first example of the Pd­(II)-catalyzed enantioselective amination of aryl C–H bonds is reported. The key to the successful realization of this asymmetric catalytic transformation was the identification of mono-N-protected α-amino-O-methylhydroxamic acid (MPAHA) ligands, which promote reactivity under mild conditions and control enantioselectivity. The counteranions in the solvent medium, hexafluoroacetylacetate and acetate, were also found to play key roles in stereocontrol and reactivity enhancement.

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