ol0c02216_si_001.pdf (7.69 MB)
Ligand-Accelerated Palladium(II)-Catalyzed Enantioselective Amination of C(sp2)–H Bonds
journal contribution
posted on 2020-07-31, 22:29 authored by Xiu-Fen Cheng, Fan Fei, Yan Li, Yi-Ming Hou, Xin Zhou, Xi-Sheng WangThe first example of the Pd(II)-catalyzed
enantioselective amination
of aryl C–H bonds is reported. The key to the successful realization
of this asymmetric catalytic transformation was the identification
of mono-N-protected α-amino-O-methylhydroxamic acid (MPAHA) ligands, which promote reactivity
under mild conditions and control enantioselectivity. The counteranions
in the solvent medium, hexafluoroacetylacetate and acetate, were also
found to play key roles in stereocontrol and reactivity enhancement.