ol034641l_si_001.pdf (119.81 kB)
Download file

Lewis Base Activation of Lewis Acids. Catalytic Enantioselective Addition of Silyl Enol Ethers of Achiral Methyl Ketones to Aldehydes

Download (119.81 kB)
journal contribution
posted on 05.06.2003, 00:00 by Scott E. Denmark, John R. Heemstra
A highly enantioselective addition of silyl enol ethers derived from simple methyl ketones is described. The catalyst system of silicon tetrachloride activated by a chiral bisphosphoramide (R,R)-7 effectively promotes the addition of a variety of unsubstituted silyl enol ethers to aromatic, olefinic, and heteroaromatic aldehydes in excellent yield.

History