Lewis Acid-Mediated Cycloaddition of
Methylenecyclopropanes with Aldehydes
and Imines:  A Facile Access to Indene,
THF, and Pyrrolidine Skeletons via
Homoallylic Rearrangement Protocol

Shi, Min; Xu, Bo; Huang, Jin-Wen

doi:10.1021/ol0498242.s001

Lewis Acid-Mediated Cycloaddition of Methylenecyclopropanes with Aldehydes and Imines: A Facile Access to Indene, THF, and Pyrrolidine Skeletons via Homoallylic Rearrangement Protocol

journal contribution

posted on 2004-04-01, 00:00 authored by Min Shi, Bo Xu, Jin-Wen Huang

Methylenecyclopropanes (MCPs) 1 can react with aldehydes and aldimines to give the corresponding indene, THF, and pyrrolidine cycloaddition products in the presence of BF₃·OEt₂ under mild reaction conditions.

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Keywords

BF presence Imine reaction conditions Facile Access Aldehyde Pyrrolidine Skeletons aldehyde OEt Indene pyrrolidine cycloaddition products THF aldimine Lewis indene Cycloaddition Homoallylic Rearrangement Protocol Methylenecyclopropanes MCP

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