ol6b00047_si_001.pdf (12.95 MB)
Lewis Acid Catalyzed Regioselective Hydroheteroarylation of Pentafulvenes
journal contribution
posted on 2016-02-10, 00:00 authored by S. Sarath Chand, Greeshma Gopalan, P. V. Santhini, P. Preethanuj, Jubi John, Dominique Harakat, Florian Jaroschik, K. V. RadhakrishnanA diverse approach toward the catalytic
regioselective nucleophilic
addition of nitrogen heterocycles to Lewis acid activated pentafulvenes
has been established. The developed protocol introduces pentafulvenes
as nonsymmetrical alkenes for the hydroheteroarylation reaction, providing
alkylidenecyclopentenylation at the C-3 position of indoles and the
C-2 position of pyrrole.