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Lewis Acid Catalyzed α-Functionalization of Ketals for the Regioselective Synthesis of α-Carbamoyl Ketals

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journal contribution
posted on 20.02.2016, 15:42 by Philip Magnus, Alec J. Brozell
Treatment of 1 with DEAD in the presence of BF3·OEt2 gave 2 (R = H), which was N-alkylated to give 2 (R = CH2CO2Et), and insitu eliminated (E1cb) to give α-carbamoyl ketals.