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Lewis Acid/Brønsted Acid Controlled Pd(II)-Catalyzed Chemodivergent Functionalization of C(sp2)–H Bonds with N‑(Arylthio)i(a)mides

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journal contribution
posted on 18.05.2018, 13:04 by Manthena Chaitanya, Pazhamalai Anbarasan
An efficient and chemodivergent palladium-catalyzed thiolation (C–S) and imidation (C–N) of directing group-assisted C–H bonds have been accomplished employing N-(arylthio)­imides in combination with either Brønsted acid or Lewis acid, respectively. Notable features of the developed methodologies include excellent diversity, high functional group tolerance, wide substrate scope, and use of a single N–S reagent. Importantly, the developed hypothesis was also successfully extended to the amidation of C–H bonds. A plausible mechanistic pathway was proposed based on the preliminary mechanistic study.

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