American Chemical Society
ol036071v_si_002.pdf (1.57 MB)

Leucascandrolide A:  A Second Generation Formal Synthesis

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journal contribution
posted on 2003-12-25, 00:00 authored by David R. Williams, Samarjit Patnaik, Scott V. Plummer
A convergent, second generation formal synthesis of (+)-Leucascandrolide A (1) has been efficiently achieved by providing a flexible, enantiocontrolled strategy toward the bioactive macrolactone component. Advancements for stereocontrol in asymmetric allylation methodology are discussed. Efforts feature novel results for reductions using the Terashima hydride reagent.