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Ketyl−Allene Cyclizations Promoted by Samarium(II) Iodide

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journal contribution
posted on 01.04.2005, 00:00 by Gary A. Molander, Elizabeth Pollina Cormier
Samarium(II) iodide has proven to be an effective reagent for intramolecular reductive coupling reactions. Previous investigations of intramolecular ketyl−olefin coupling reactions provided carbocycles in excellent yield and good diastereoselectivity. This method has been extended to ketyl cyclizations with allenes. Substrates leading to both carbocycles and heterocycles in a selective manner are explored.