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Ketene Aminal Phosphates: Competent Substrates for Enantioselective Pd(0)-Catalyzed C–H Functionalizations

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journal contribution
posted on 26.09.2017, 00:00 by Daria Grosheva, Nicolai Cramer
Enantioselective Pd­(0)-catalyzed C–H functionalizations of ketene aminal phosphates provide isoindoline scaffolds with high enantioselectivity at ambient temperature. The high level of enantiocontrol is enabled by a tailored monodentate electron-rich phosphine ligand featuring a point-chiral phospholane module and a bulky atropchiral binaphthyl backbone.