ol2c00387_si_001.pdf (8.38 MB)
K2S2O8/I2‑Promoted Electrophilic Selenylative Cyclization To Access Seleno-Benzo[b]azepines
journal contributionposted on 2022-03-23, 13:04 authored by Zhen Zhang, Shilong Wang, Pengpeng Tan, Xiaowen Gu, Wenjie Sun, Chang Liu, Jinchun Chen, Jiazhu Li, Kai Sun
A novel and simple organoselenium-involved 7-membered cyclization to access diverse seleno-benzo[b]azepines has been developed. This protocol involves an electrophilic cyclization process and is accomplished under mild conditions. Discussion of the mechanism rationalizes the regioselectivity observed in transformation. The studies of further transformation of seleno-benzo[b]azepines and large-scale experiment reveal the promising utility of this methodology.