Juniperolide A: A New Polyketide Isolated from a Terrestrial Actinomycete, Streptomyces sp.
journal contributionposted on 07.12.2012, 00:00 by Ritesh Raju, Oleksandr Gromyko, Viktor Fedorenko, Andriy Luzhetskyy, Alberto Plaza, Rolf Müller
A new linear polyketide, juniperolide A (1), was produced by the terrestrial actinomycete (Lv1-48) isolated from the rhizosphere of the plant Juniperus excelsa. The juniperolide A (1) structure contains a THP unit and a 3-amino-2,3,6-trideoxyhexose as the glycosidic moiety. Mosher’s analysis was used for absolute stereochemistry determinations at C-2, C-8, C-20, and C-4′, while the relative stereochemistry assignments of the remaining stereocenters were based on ROESY correlations and J-based coupling.