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Janus Nanocage toward Platelet Delivery

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journal contribution
posted on 02.05.2016, 00:00 by Lin Tang, Saina Yang, Fuxin Liang, Qian Wang, Xiaozhong Qu, Zhenzhong Yang
The platelet-shaped Janus nanocages with a mesoporous silica shell are prepared. PEG moiety onto the exterior surface is responsible for good dispersity in water. The graphene sheet inside the cavity is responsible for hydrophobic performance to selectively capture hydrophobic species, and photothermal effect by NIR irradiation. As a biocompatible DOX-loaded Janus platelet delivery, HeLa cell cytotoxicity is greatly enhanced under NIR irradiation. There exists a synergetic effect between the chemotherapy and photothermal therapy.