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Jaboticabin and Related Polyphenols from Jaboticaba (Myrciaria cauliflora) with Anti-inflammatory Activity for Chronic Obstructive Pulmonary Disease
journal contribution
posted on 2019-01-23, 21:44 authored by Da-Ke Zhao, Ya-Na Shi, Vanya Petrova, Grace G. L. Yue, Adam Negrin, Shi-Biao Wu, Jeanine M. D’Armiento, Clara B. S. Lau, Edward J. KennellyMyrciaria cauliflora (jaboticaba)
is an edible fruit common in Brazil that has been used for treating
respiratory diseases, including chronic tonsillitis and asthma. This
study explores the distribution of an anti-inflammatory depside, jaboticabin,
in different parts of the jaboticaba plant as well as major polyphenols
from the wood of jaboticaba, some with biological activity similar
to jaboticabin. The peel of the fruit was found to be the major source
of jaboticabin. This is the first phytochemical study of the wood
of M. cauliflora. The antioxidant-activity-guided
fractionation strategy successfully identified 3,3′-dimethylellagic
acid-4-O-sulfate from jaboticaba wood. This ellagic
acid derivative, in a manner similar to jaboticabin, showed antiradical
activity and inhibited the production of the chemokine interleukin-8
after treating the human small airway epithelial cells with cigarette
smoke extract. The human intestinal Caco-2 cell studies demonstrated
the jaboticabin transport in vitro. The polyphenols,
jaboticabin and 3,3′-dimethyellagic acid-4-O-sulfate, from jaboticaba were both found to exhibit anti-inflammatory
activities, thus suggesting the potential use of these compounds or
even the fruits themselves for chronic obstructive pulmonary disease.
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Myrciaria caulifloraanti-inflammatory depsideellagic acidairway epithelial cellsCaco -2 cell studiesAnti-inflammatory Activitycigarette smokejaboticabin transportchemokine interleukin -8jaboticaba woodRelated PolyphenolsChronic Obstructive Pulmonary Disease Myrciaria caulifloraphytochemical studyantiradical activityexhibit anti-inflammatory activitiesantioxidant-activity-guided fractionation strategyjaboticaba plant
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