Isoxazolone Based Inhibitors of p38 MAP Kinases
journal contributionposted on 24.04.2008, 00:00 by Stefan A. Laufer, Simona Margutti
SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.