ol0c02266_si_001.pdf (5.32 MB)
Isothiourea-Catalyzed Atroposelective N‑Acylation of Sulfonamides
journal contribution
posted on 2020-08-11, 20:05 authored by Jun-Yang Ong, Xiao Qian Ng, Shenci Lu, Yu ZhaoWe report herein
an atroposelective N-acylation of sulfonamides
using a commercially available isothiourea catalyst, (S)-HBTM, with a simple procedure. The N-sulfonyl
anilide products can be obtained in good to high enantiopurity, which
represents a new axially chiral scaffold. The application of the product
as a chiral iodine catalyst is also demonstrated for the asymmetric
α-oxytosylation of propiophenone.