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Isoquinoline Derivatives via Stepwise Regioselective sp2 and sp3 C–H Bond Functionalizations

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journal contribution
posted on 21.02.2016, 15:22 by Tarek Boudiar, Zeyneb Sahli, Basker Sundararaju, Mathieu Achard, Zahia Kabouche, Henri Doucet, Christian Bruneau
Efficient and practically attractive stepwise ruthenium- and palladium-catalyzed regioselective C–H bond functionalizations were achieved to produce 4-substituted tetrahydroisoquinoline derivatives featuring various heteroaromatic substructures in moderate to good yields. Both ruthenium- and palladium-based catalytic processes generated nontoxic and easily separable side products.