np0c00026_si_001.pdf (4.47 MB)
Isolation of 2‑Alkyl-4-quinolones with Unusual Side Chains from a Chinese Pseudomonas aeruginosa Isolate
journal contribution
posted on 2020-06-30, 18:34 authored by Jianye Li, Weiwei Sun, Muhammad Saalim, Guixiang Wei, Diana A. Zaleta-Pinet, Benjamin R. ClarkChemical investigation of a Pseudomonas aeruginosa strain isolated from Hebei, China,
led to the isolation of a suite
of quinolones, quinolone-N-oxides, and phenazines,
the structures of which were elucidated by detailed spectroscopic
analysis. Most notable among the secondary metabolites isolated was
an unprecedented 4-quinolone containing an S-methyl
group in the side chain and a new derivative including a phenyl ring
in the side chain, which expand significantly the variety of structural
motifs found in the quinolones and raise interesting questions about
their biosynthesis.