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Isolation and Characterization of Aphidicolin and Chlamydosporol Derivatives from Tolypocladium inflatum

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posted on 2011-08-26, 00:00 authored by Jie Lin, Xiaoyan Chen, Xiaoyue Cai, Xinfang Yu, Xingzhong Liu, Ya Cao, Yongsheng Che
Six new secondary metabolites including two aphidicolin analogues, inflatins A (1) and B (2), and four chlamydosporol derivatives, inflatins C–F (36), have been isolated from the crude extract of Tolypocladium inflatum. The structures of 16 were determined mainly by NMR experiments, and 4 and 5 were further confirmed by X-ray crystallography. The absolute configurations of C-16 in 1 and C-5 in 3 were deduced via the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complexes, whereas that of 4 was assigned by X-ray crystallography using Cu Kα radiation. Compounds 1 and 2 showed modest cytotoxicity against a panel of eight human tumor cell lines.

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