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Isocoumarin Glucosides from the Scale Insect Fungus Torrubiella tenuis BCC 12732

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journal contribution
posted on 24.07.2009, 00:00 by Jittra Kornsakulkarn, Chawanee Thongpanchang, Sanisa Lapanun, Kitlada Srichomthong
Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3-methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 5 exhibited moderate anti-HSV-1 and antimycobacterial activities with IC50 and MIC values of 50 and 25 μg/mL, respectively.