jf7b06057_si_001.pdf (12.52 MB)
Isobutylhydroxyamides from Sichuan Pepper and Their Protective Activity on PC12 Cells Damaged by Corticosterone
journal contribution
posted on 2018-03-14, 00:00 authored by Jiahuan Chen, Tao Zhang, Qiubo Zhang, Yang Liu, Lingyu Li, Jinguang Si, Zhongmei Zou, Huiming HuaThe pericarp of Zanthoxylum
bungeanum Maxim.,
commonly known as Sichuan pepper, is a widely used spice to remove
fishy odor and add palatable taste. A phytochemical investigation
of the 95% ethanol extract of Sichuan pepper resulted in the isolation
of 21 isobutylhydroxyamides, including 8 new ones named ZP-amides
G–N, among which the chiral resolution of racemic ZP-amide
A and ZP-amide B was successfully accomplished. The protective activity
on corticosterone-treated PC12 cells of the isolated isobutylhydroxyamides
was also evaluated. The new compounds 3–5 and the known compounds 1, 1a, 2, 2a, 11, and 15 improved
the survival rate of PC12 cells. The bioactivity studies disclosed
the potential of Sichuan pepper to be developed as new neuroprotective
functional food.