posted on 2014-05-02, 00:00authored byWenbin Du, Lixia Tian, Junshan Lai, Xing Huo, Xingang Xie, Xuegong She, Shouchu Tang
An
alternative method to an iron-catalyzed radical oxidative cross-coupling
reaction followed by 2-chloro-1,3-dithiane and aryl olefins for the
synthesis of β-chloro substituent 1,3-dithiane products is presented.
The described method has the advantage of mildness of the reaction
conditions and tolerates a variety of functional groups. Preliminary
mechanistic studies have confirmed the first example of a coupling
of 1,3-dithiane with unactivated alkenes that proceeds via an iron-catalyzed
oxidative radical intermediate along the reaction pathway.