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Iron-Catalyzed Regioselective Remote C(sp2)‑H Carboxylation of Naphthyl and Quinoline Amides

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journal contribution
posted on 02.08.2019, 17:35 authored by Sandeep Kumar, Sourav Pradhan, Subhasish Roy, Pinaki Bhusan De, Tharmalingam Punniyamurthy
Iron­(III)-catalyzed regioselective direct remote C–H carboxylation of naphthyl and quinoline amides was developed using CBr4 and alcohol. The reaction involves a radical pathway using a coordination activation strategy and single electron transfer process. The use of sustainable iron catalysis, selectivity, and the substrate scope are the important practical features.