Iron-Catalyzed
Intramolecular C(sp3)‑H
Lactonization of Hydroxamate Derivatives Promoted by a 1,5-HAT

Esteves, Hugo; Xavier, Tania; Lajnef, Sonia; Peyrot, Fabienne; Lefèvre, Guillaume; Prestat, Guillaume; Berhal, Farouk

doi:10.1021/acscatal.3c04900.s001

cs3c04900_si_001.pdf (6.15 MB)

Iron-Catalyzed Intramolecular C(sp³)‑H Lactonization of Hydroxamate Derivatives Promoted by a 1,5-HAT

journal contribution

posted on 2024-03-06, 20:14 authored by Hugo Esteves, Tania Xavier, Sonia Lajnef, Fabienne Peyrot, Guillaume Lefèvre, Guillaume Prestat, Farouk Berhal

An iron-catalyzed lactonization reaction via intramolecular C(sp³)-H functionalization is described. The process employs easily accessible hydroxamate derivatives from which the noncommon insertion of the oxygen occurred through a 1,5-hydrogen atom transfer. A mixture of water and hexafluoroisopropanol as solvent appeared to be the key parameter of this transformation to reach a high selectivity and efficiency.