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Iriomoteolide-3a, a Cytotoxic 15-Membered Macrolide from a Marine Dinoflagellate Amphidinium Species

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journal contribution
posted on 15.02.2008, 00:00 by Keiko Oguchi, Masashi Tsuda, Rie Iwamoto, Yumiko Okamoto, Jun'ichi Kobayashi, Eri Fukushi, Jun Kawabata, Tomoko Ozawa, Atsunori Masuda, Yoshiaki Kitaya, Kenji Omasa
A 15-membered macrolide, iriomoteolide-3a (1), with an allyl epoxide has been isolated from a marine benthic dinoflagellate Amphidinium sp. (strain HYA024), and the structure was assigned by detailed analyses of 2D NMR data. Relative and absolute configurations were elucidated on the basis of conformational studies of 1 and its acetonide (2) and modified Mosher's method of 1, respectively. Iriomoteolide-3a (1) and the acetonide (2) exhibited potently cytotoxic activity against antitumor cells.