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Iridium-Catalyzed Enantioselective Polyene Cyclization

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journal contribution
posted on 19.12.2012, 00:00 by Michael A. Schafroth, David Sarlah, Simon Krautwald, Erick M. Carreira
A highly enantioselective polycyclization method has been developed using the combination of Lewis acid activation with iridium-catalyzed allylic substitution. This strategy relies on direct use of branched, racemic allylic alcohols and furnishes a diverse and unique set of carbo- and heteropolycyclic ring systems in good yields and ≥99% ee.