posted on 2013-11-01, 00:00authored byDonggun Lee, Youngchan Kim, Sukbok Chang
Iridium-catalyzed direct ortho C–H
amidation of arenes has
been shown to work well with sulfonyl- and aryl azides as the nitrogen
source. The reaction proceeds efficiently with a broad range of substrates
bearing conventional directing groups with excellent functional group
compatibility under mild conditions. In addition, substrates forming
not only 5- but also 6-membered iridacycle intermediates undergo the
C–H amidation with high selectivity.