Iridium-Complex-Functionalized Magnetic Nanoparticles for Fluorescent Detection of Mercapto Drugs

Current research on various fluorescence sensors based on metal complexes has become popular. Herein, a robust, rapid fluorescence response system was first established by combining the highest active iridium complex (Ir-3)-functionalized magnetic bead (MB@Ir-3) and natural fluorescent probe NAD⁺, which have the characteristics of high reaction speed, sensitivity, easy quenching, and pollution-free. Furthermore, the fluorescence response system demonstrated an ultrasensitive and rapid detection performance for various mercapto compounds (cysteine, reduced glutathione, and captopril) and captopril real samples in commercial pharmaceutical tablet and urine samples. Thus, the established fluorescence methods have provided a potential platform for mercapto medicine determination in the clinic.