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Iridium-Catalyzed Regioselective Synthesis of Trifluoromethylated Isocoumarins through Annulation of Benzoic Acids with Trifluoromethylated Alkynes

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journal contribution
posted on 26.03.2019, 11:34 authored by Guangyuan Liu, Guanghua Kuang, Xingxing Zhang, Naihao Lu, Yang Fu, Yiyuan Peng, Yirong Zhou
An unprecedented Ir-catalyzed oxidative coupling of benzoic acids with trifluoromethylated alkynes was successfully developed to provide diverse trifluoromethylated isocoumarins in moderate to good yields. This new practical procedure was highlighted by mild reaction conditions, broad substrate scope, good regioselectivity, high efficiency, and easy operation.