ol9b00572_si_001.pdf (5.68 MB)
Iridium-Catalyzed Regioselective Synthesis of Trifluoromethylated Isocoumarins through Annulation of Benzoic Acids with Trifluoromethylated Alkynes
journal contribution
posted on 2019-03-26, 11:34 authored by Guangyuan Liu, Guanghua Kuang, Xingxing Zhang, Naihao Lu, Yang Fu, Yiyuan Peng, Yirong ZhouAn
unprecedented Ir-catalyzed oxidative coupling of benzoic acids with
trifluoromethylated alkynes was successfully developed to provide
diverse trifluoromethylated isocoumarins in moderate to good yields.
This new practical procedure was highlighted by mild reaction conditions,
broad substrate scope, good regioselectivity, high efficiency, and
easy operation.