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Iridium-Catalyzed Regioselective Hydroalkynylation of Internal Alkenes Directed by an Oxime

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journal contribution
posted on 03.12.2021, 18:35 by Peng-Chao Gao, Zi-Xuan Wang, Bi-Jie Li
We report here an iridium-catalyzed hydroalkynylation of allylic alcohols protected by an oxime group. Catalytic alkynylation occurs exclusively at the distal position of the alkene. This method generates γ-alkynyl alcohol oximes directly from internal alkenes and terminal alkynes. The oxime group can be readily removed to afford a free alcohol, thus providing an indirect route for the catalytic hydroalkynylation of allylic alcohols.