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Iridium-Catalyzed Asymmetric Hydrogenation of Sterically Hindered Cyclic Imines for Enantioselective Synthesis of Tetrahydroisoquinolines

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journal contribution
posted on 22.12.2020, 19:39 by Bin Li, Ruixia Liu, Jing Yang, Jingyuan Luo, Lin Yao, Muqiong Li, Xiaohui Zheng, Ru Jiang, Huifang Nie, Shengyong Zhang
An efficient enantioselective hydrogenation of sterically hindered cyclic imines catalyzed by the Ir-tBu-ax-Josiphos complex has been described, producing a series of useful chiral bulky tetrahydroisoquinoline analogs in high isolated yields (85–96%) with good to excellent enantioselectivities (74–99% ee). This transformation provided highly straightforward access to the useful derivatives of tetrahydroisoquinolines, which are of great potential value in drug molecule and natural product research.