jo0c00999_si_001.pdf (3.55 MB)
Ir(III)-Catalyzed C–H Functionalization of Triphenylphosphine Oxide toward 3‑Aryl Oxindoles
journal contributionposted on 2020-09-29, 10:43 authored by Qin-Xin Lou, Yuan Niu, Zhi-Chao Qi, Shang-Dong Yang
With triphenylphosphine oxide serving as both the directing group and the reagent, we have developed a Cp*Ir(III)-catalyzed direct C–H functionalization of triphenylphosphine oxide with 3-diazooxindoles to afford a range of 3-(2-(diphenylphosphoryl)phenyl)indolin-2-one derivatives in moderate to excellent yields. The title products are potentially important building blocks for organic synthesis through various chemical transformations. This protocol is simple and efficient and offers high atom economy with only N2 as the byproduct.