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Ionic Cocrystals of Etiracetam and Levetiracetam: The Importance of Chirality for Ionic Cocrystals
journal contribution
posted on 2019-03-04, 00:00 authored by Lixing Song, Oleksii Shemchuk, Koen Robeyns, Dario Braga, Fabrizia Grepioni, Tom LeyssensA striking
variety of anhydrous and hydrated ionic cocrystals (ICCs) of the enantiopure
antiepileptic drug (AED) levetiracetam and of its racemic intermediate
etiracetam with the pharmaceutically acceptable salts CaCl2 and MgCl2 was synthesized and structurally characterized.
The difference in the interaction of enantiopure and racemic compounds
of interest with the inorganic salts was investigated. Variable-temperature
X-ray powder diffraction (VT-XRPD) and calorimetric analyses (TGA
and DSC) of all obtained ICCs showed a significant improvement in
thermal stability with respect to pure racetams.