jo7b00073_si_001.pdf (6.55 MB)
Iodine-Catalyzed Cross Dehydrogenative Coupling Reaction: Sulfenylation of Enaminones Using Dimethyl Sulfoxide as an Oxidant
journal contribution
posted on 2017-02-23, 00:00 authored by Yogesh Siddaraju, Kandikere Ramaiah PrabhuSynthesis
of polyfunctionalized aminothioalkenes has been demonstrated
using iodine as a catalyst (30 mol %) and dimethyl sulfoxide as an
oxidant under metal-free reaction conditions. This methodology allows
a facile sulfenylation of enaminones with a broad range of heterocyclic
thiols and thiones using cross dehydrogenative coupling methods. In
addition, this strategy is highly practical as it employs inexpensive
and readily available iodine and DMSO with a short reaction time.
The current methodology is one of the simplest methods and provides
a straightforward approach to sulfenylation of enaminones via the
cross dehydrogenative coupling method.