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Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

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journal contribution
posted on 08.06.2016, 17:04 by Pieter Mampuys, Yanping Zhu, Sergey Sergeyev, Eelco Ruijter, Romano V. A. Orru, Sabine Van Doorslaer, Bert U. W. Maes
A new method for the synthesis of secondary thiocarbamates from readily available isocyanides and thiosulfonates with broad functional group tolerance is reported. The reaction proceeds under mild reaction conditions in isopropanol and is catalyzed by inexpensive sodium iodide.