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Investigation of the Scope and Regiochemistry of Alkynylboronate Cycloadditions with Sydnones

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journal contribution
posted on 10.06.2009, 00:00 by Duncan L. Browne, Jérôme F. Vivat, Andrew Plant, Enrique Gomez-Bengoa, Joseph P. A. Harrity
The cycloaddition of alkynylboronates and sydnones provides a convenient and highly regioselective method for the synthesis of a broad range of di-, tri-, and tetrasubstituted pyrazole boronic esters. The origins of an observed regiochemical divergence in the reactions of terminal alkynylboronates with their more substituted analogues have been studied by DFT methods.