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Investigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core

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journal contribution
posted on 18.09.2019, 13:09 by Anamika Sharma, Rotimi Sheyi, Ashish Kumar, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio
An example of triorthogonal chemoselectivity is reported here for the first time. In this regard, a series of 43 reactions were performed using tridentate s-triazine as a model. In all of the possible cases, the three substitutions were carried out using different nucleophiles at a temperature compatible with biological systems.