ol6b00464_si_003.pdf (11 MB)
Download fileInverse Electron-Demand [4 + 2]-Cycloadditions of Ynamides: Access to Novel Pyridine Scaffolds
journal contribution
posted on 2016-03-21, 18:05 authored by Guillaume Duret, Robert Quinlan, Rainer
E. Martin, Philippe Bisseret, Markus Neuburger, Vincent Gandon, Nicolas BlanchardFunctionalized polycyclic aminopyridines
are central to the chemical
sciences, but their syntheses are still hampered by a number of shortcomings.
These nitrogenated heterocycles can be efficiently prepared by an
intramolecular inverse electron demand hetero Diels–Alder (ihDA) cycloaddition of ynamides to pyrimidines. This ihDA/rDA
sequence is general in scope and affords expedient access to novel
types of aminopyridinyl scaffolds that hold great promise in terms
of exit vector patterns.
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InversesequenceAccessYnamideshortcomingcycloadditionaccessnitrogenated heterocyclesynamideaminopyridinyl scaffoldsihDADielscopeintramolecularpromisechemical scienceselectronsynthesepyrimidinedemandtermexit vector patternsNovel Pyridine Scaffolds Functionalized polycyclic aminopyridinesCycloadditionnovel types