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Introducing a New Class of N-Phosphoryl Ynamides via Cu(I)-Catalyzed Amidations of Alkynyl Bromides

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journal contribution
posted on 16.09.2011, 00:00 by Kyle A. DeKorver, Mary C. Walton, Troy D. North, Richard P. Hsung
We describe here the first synthesis of N-phosphoryl ynamides featuring C- and P-chirality via copper(I)-catalyzed amidative cross-couplings between phosphoramidates and phosphordiamidates with alkynyl bromides. Also featured is a tandem aza-Claisen–hetero-[2 + 2] cycloaddition for the synthesis of N-phosphoryl azetidin-2-imines.