Intramolecular Iron-Mediated Diene/Olefin Cyclocoupling:  Formation of
Carbon Spirocycles

Pearson, Anthony J.; Wang, Xiaolong; Dorange, Ismet B.

doi:10.1021/ol040036m.s001

Intramolecular Iron-Mediated Diene/Olefin Cyclocoupling: Formation of Carbon Spirocycles

https://doi.org/10.1021/ol040036m.s001
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journal contribution

posted on 2004-07-22, 00:00 authored by Anthony J. Pearson, Xiaolong Wang, Ismet B. Dorange

A short and convenient diastereoselective synthesis of all-carbon spirocylic molecules was developed. A straightforward protocol that involves rearrangement of the diene−Fe(CO)<sub>3</sub> complex followed by cyclization delivers the desired product. The reaction substrates were easily prepared by reaction of an appropriate nucleophile and a cyclohexadienyl-Fe(CO)<sub>3</sub> cation.