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Intramolecular Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide

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journal contribution
posted on 15.06.2016, 17:34 by Jian Wang, Shi Tang, Qiang Zhu
Efficient access to five- to seven-membered cyclic ketoimines, through palladium-catalyzed intramolecular imidoylative Heck reaction of alkene-containing isocyanides, has been developed. Consecutive isocyanide and alkene insertion into aryl or alkyl Pd­(II) intermediates takes place in this process. No byproduct derived from monoinsertion or reversed sequence is detected.

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