American Chemical Society
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Intramolecular Diels−Alder Reactions of Cyclopropenone Ketals

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journal contribution
posted on 2010-08-06, 00:00 authored by Paresma R. Patel, Dale L. Boger
The first intramolecular cycloaddition reactions of cyclopropenone ketals with tethered electron-deficient, electron-rich, and neutral 1-substituted dienes are reported, constituting inverse electron demand, normal, and neutral Diels−Alder reactions, that provide exclusively the exo [4 + 2] cycloaddition products without the intervention of [1 + 2], [3 + 2], or [3 + 4] cycloadducts in reactions whose courses do not depend on the reaction conditions, the diene activating substituent, or the nature of the tethering.